VISDB Viral Integration Site DataBase

VIS ID

TVIS10014866

Fusion event

HBV-THRB integration

Validated

Yes

Detection method

PCR and Sanger sequencing

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Normal

Reported year

2012

PubMed ID

Virus name

HBV

Reference genome

Start

2141

Integrated sequence

TGTTCACCTCACCATACAGCACTCAGGCAAGCTATTCTGTGTTGGGGTGAGTTGATGAATCTGGCCACCTGGGTGGGAAGTAATTTGGAAGACCCAGCAT| |CCAGGGAATTAGTAGTCAGCTATGTCAATGTTAATATGGGCCTAAAAATTAGACAACTATTGTGGTTTCACATTTCCTGCCTTACTTTTGGAAGAGAAAC

Chromosome

chr3

Cytoband

p24.2

Reference genome

Start

End

24499331/24457840 (Hg38)

Location type

Intronic

Fragile sites / regions

Target gene

miRNAs that regulate target gene

hsa-mir-27a-3p ; hsa-mir-204-5p ; hsa-mir-155-5p ; hsa-mir-425-5p ; hsa-mir-452-5p ; hsa-mir-4677-3p ; hsa-mir-4679 ; hsa-mir-3161 ; hsa-mir-3689f ; hsa-mir-3689e ; hsa-mir-3689b-5p ; hsa-mir-3689a-5p ; hsa-mir-3926 ; hsa-mir-4778-5p ; hsa-mir-4753-5p ; hsa-mir-6794-3p ; hsa-mir-3152-5p ; hsa-mir-6836-3p ; hsa-mir-15b-3p ; hsa-mir-4264 ; hsa-mir-4797-3p ; hsa-mir-6809-3p ; hsa-mir-4753-3p ; hsa-mir-4436b-5p ; hsa-mir-6509-3p ; hsa-mir-1236-3p ; hsa-mir-6515-3p ; hsa-mir-101-3p ; hsa-mir-200a-3p ; hsa-mir-1238-5p ; hsa-mir-129-5p ; hsa-mir-3659 ; hsa-mir-4658 ; hsa-mir-4758-5p ; hsa-mir-574-5p ; hsa-mir-6790-5p ; hsa-mir-8055 ; hsa-mir-8081 ; hsa-mir-1537-5p ; hsa-mir-320a ; hsa-mir-320b ; hsa-mir-320c ; hsa-mir-320d ; hsa-mir-3607-3p ; hsa-mir-4429 ; hsa-mir-4633-3p ; hsa-mir-4793-5p ; hsa-mir-5002-5p ; hsa-mir-5196-3p ; hsa-mir-6500-5p ; hsa-mir-6870-3p ; hsa-mir-6874-5p ; hsa-mir-9-3p

Nearest miRNA

hsa-mir-12127/Upstream/4320199; hsa-let-7g/Downstream/1207033;

Nearest TSS

Nearest CpG islands

None/Target, chr3-CpG: 148/Upstream/511310, chr3-CpG: 135/Downstream/36513

Nearest cancer related gene

THRB(TSG, No orient, 0)

Upstream sequence

gcgggcggatcacaaggtcaggagatcaagaccaccctggctaacacggtgaaaccccTCGATGATAGTTccattcgattctatgcgatgattccattcc

Downstream sequence

gtgaggacatttgcctttagagtagagttaggcgcatttgaaggctataggagctcttcagagtcatgatggtagtaattactcagtaactgctttagtg