Basic Information
VIS ID
TVIS10014879
Fusion event
HBV-chr4 integration
Validated
Yes
Detection method
PCR and Sanger sequencing
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2012
PubMed ID
22634756
Virus Sequence
Virus name
HBV
Reference genome
NC_003977.1
Start
1846
Integrated sequence
AGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGTTCACCAGCACCATGCAACTTTTTCCCCTCTGCCTAATCATCTCA| |TGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATTGACCCGTATAAAGAATTTGGAGCTTCTGTGGAGTTAC
Host Sequence
Chromosome
chr4
Cytoband
q31.3
Reference genome
GRCh37/hg19
Start
151954261/151033109 (Hg38)
End
151954261/151033109 (Hg38)
Nearest miRNA
hsa-mir-12113/Upstream/3250441; hsa-mir-1305/Downstream/1456218;
Nearest TSS
ENST00000502981/Upstream/17382; ENST00000503002/Downstream/66464;
Nearest CpG islands
None/Target, chr4-CpG: 46/Upstream/16742, chr4-CpG: 66/Downstream/66209
Nearby gene
AK4P6(-5492) ;
Upstream sequence
gtcATTCAAGCTCTTCCAAGCCACATGAAATCAATGCCAAAGTCTACAAACAAACAAAGGAGGGATTTTTCTTCTCTTCCTGTTCTTTGGCTCTGAGTTT
Downstream sequence
tacaagcacccatcaccacacccagctaatttttgaatttttagtagagacgaggtttcgccatgttggccaggctggtctcgaacccttgacctcaagt
Reference
Fujimoto, A., et al. Whole-genome sequencing of liver cancers identifies etiological influences on mutation patterns and recurrent mutations in chromatin regulators. Nat Genet,2012, 44(7): 760-764.
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