Basic Information
VIS ID
TVIS10014882
Fusion event
HBV-chr8:p11 integration
Validated
Yes
Detection method
PCR and Sanger sequencing
Data source
Curated
Sample type
Cell line
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Perfect
Reported year
2014
PubMed ID
24582836
Virus Sequence
Virus name
HBV
Reference genome
NC_003977.1
Region type
X
Start
1539
End
1622
Orient
+
Integrated sequence
GCGGTCTCCCCGTCTGTGCCTTCTCATCTGCCGGACCGTGTGCACTTCGCTTCACCTCTGCACGTAGCATGGAGACCACCGTGA
Host Sequence
Chromosome
chr8
Cytoband
p11
Reference genome
GRCh37.p10
Start
41493923/41636404 (Hg38)
End
41494204/41636685 (Hg38)
Orient
+
Nearest miRNA
hsa-mir-124-1/Upstream/365261; hsa-mir-10400/Downstream/23756;
Nearest TSS
ENST00000518652/Upstream/14902; ENST00000585088/Downstream/10674;
Nearest CpG islands
None/Target, chr8-CpG: 109/Upstream/57764, chr8-CpG: 38/Downstream/9712
Nearby gene
NKX6-3(+8773) ;
Downstream sequence
GTGTTGTTGAGGATGTGAAGTAAAGAAAACCCTTGCCTGCTCTTGGTAGGAATGTAAATTAGATTAGCTATTGTGGAAAACAGCATGGAGATTCCTAAAACTAAAACCAGAGCTTCCATATGATCCAGCAGTCCCCTACT
Target sequence
TGTTGTTGAGGATGTGAAGTAAAGAAAACCCTTGCCTGCTCTTGGTAGGAATGTAAATTAGATTAGCTATTGTGGAAAACAGCATGGAGATTCCTAAAACTAAAACCAGAGCTTCCATATGATCCAGCAGTCCCCTACTAGGAAAGGAAATCAATATATCAAAGAGATACCTGCACTCCCATGTTTATTGCAGCACTATTCACAATGACCAAGATTTGGAATCAACTTGTGTCCATCATAGATGAGTAGATAAGG
Junction sequence
CCGTCTGTGCCTTCTCATCTGCCGGACCGTGTGCACTTCGCTTCACCTCTGCACGTCGCATGGAAACCACCGTGTTGTTGAGGATGTGAAGTAAAGAAAACCCTTGCCTGCTCTTGGTAGGAATGTAAATTAGATTAGCTATTGTGGAAAACAGCATGGAGATTCCTAAAACTAAAACCAGAGCTTCCATATGATCCAGCAGTCCCCTACT
* Color:  Human Sequence / Virus Sequence / Overlapped sequence / Unknown sequence
Reference
Lau, C. C., et al. Viral-human chimeric transcript predisposes risk to liver cancer development and progression. Cancer Cell ,2014,25(3): 335-349.
Curate