Basic Information
VIS ID
TVIS10014888
Fusion event
HBV-chr11:q13 integration
Validated
Yes
Detection method
PCR and Sanger sequencing
Data source
Curated
Sample type
Cell line
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Perfect
Reported year
2014
PubMed ID
24582836
Virus Sequence
Virus name
HBV
Reference genome
NC_003977.1
Region type
Core
Start
1842
End
1936
Orient
+
Integrated sequence
CTCATGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATTGACCCGTATAAAGAATTTGGAGCTTCTG
Host Sequence
Chromosome
chr11
Cytoband
q13
Reference genome
GRCh37.p10
Start
68887645/69120109 (Hg38)
End
68887577/69120177 (Hg38)
Orient
-
Fragile sites / regions
FRA11H ; FRA11A
Nearest miRNA
hsa-mir-10392/Upstream/36851; hsa-let-7a-2/Downstream/1163778;
Nearest TSS
ENST00000527297/Upstream/16616; ENST00000641280/Downstream/35301;
Nearest CpG islands
None/Target, chr11-CpG: 30/Upstream/37026, chr11-CpG: 30/Downstream/37045
Upstream sequence
AATGCAAGCCACAAGGATAGGACTTGGTCTGTTCT
Target sequence
GAACAGACCAAGTCCTATCCTTGTGGCTTGCATTCTCATGGGATCAGAGACTCAGCCCCCTGGGGAAG
Junction sequence
AATGCAAGCCACAAGGATAGGACTTGGTCTGTTCTCTTGTTCATGTTCCACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGAGCATGGACATTGA
* Color:  Human Sequence / Virus Sequence / Overlapped sequence / Unknown sequence
Reference
Lau, C. C., et al. Viral-human chimeric transcript predisposes risk to liver cancer development and progression. Cancer Cell ,2014,25(3): 335-349.
Curate