Basic Information
VIS ID
TVIS10014892
Fusion event
HBV-LOC100132126 integration
Validated
No
Detection method
WGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2012
PubMed ID
22634754
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
HBVgp1 Polymerase
Start
2454
Orient
-
Integrated sequence
ACGAGGCAGGTCCCCTAGAAGAAGAACTCCCTCGCCTCGCAGACGAAGGTCTCAATCGCCGCGTCGCAGAAGATCTCAATCTCGGGAATCTCAATGTTAG| |TATTCCTTGGACTCATAAGGTGGGGAACTTTACTGGGCTTTATTCTTCTACTGTACCTGTCTTTAATCCTCATTGGAAAACACCATCTTTTCCTAATATA
Host Sequence
Chromosome
chr12
Cytoband
q22
Reference genome
GRCh37/hg19
Start
92924609/92530833 (Hg38)
End
92924609/92530833 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA12B
Target gene
LOC100132126
Nearest miRNA
hsa-let-7i/Upstream/5785684; hsa-mir-1178/Downstream/2030956;
Nearest TSS
ENST00000382841/Upstream/64382; ENST00000397833/Downstream/172010;
Nearest CpG islands
None/Target, chr12-CpG: 104/Upstream/384276, chr12-CpG: 133/Downstream/397733
Upstream sequence
AGGACCTGGAAATGTGCATAAGGAAGTCTCATCTTCCTTTGACTGAGTTATCAAGGAGACAGCTTGAGAGATGATGGCTCATTCTGCTGCTATCCTCATC
Downstream sequence
ACATATCCCTTCCATGTGATCACTCTGAGACCTGTGGTACAATTCATTGGCAGAGGACCTAAGTACTGTGGACTTTGTGACTTCATGACCATCTATCAGA
Reference
Sung, W. K., et al. Genome-wide survey of recurrent HBV integration in hepatocellular carcinoma. Nat Genet,2012, 44(7): 765-769.
Curate