VISDB Viral Integration Site DataBase

VIS ID

TVIS10014893

Fusion event

HBV-PRDM16 integration

Validated

No

Detection method

WGS

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Normal

Reported year

2012

PubMed ID

Virus name

HBV

Reference genome

Region type

HBVgp4 precore/core protein

Start

1930

Orient

+

Integrated sequence

CTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAAGAATTTG| |GAGCTACTGTGGAGTTACTCTCGTTTTTGCCTTCTGACTTCTTTCCTTCAGTACGAGATCTTCTAGATACCGCCTCAGCTCTGTATCGGGAAGCCTTAGA

Chromosome

chr1

Cytoband

p36.32

Reference genome

Start

End

3190800/3274236 (Hg38)

Orient

+

Location type

Intronic

Fragile sites / regions

Target gene

miRNAs that regulate target gene

hsa-mir-133b ; hsa-mir-133a-3p ; hsa-mir-96-5p ; hsa-mir-615-3p ; hsa-mir-346 ; hsa-mir-221-3p ; hsa-mir-101-3p

Nearest miRNA

hsa-mir-12136/Upstream/146201; hsa-mir-101-1/Downstream/286459;

Nearest TSS

Nearest CpG islands

None/Target, chr1-CpG: 111/Upstream/5976, chr1-CpG: 47/Downstream/4576

Nearest cancer related gene

PRDM16(OG, No orient, 0)

Upstream sequence

TTCTTTAATAAAAAGTGTATTTGGGATTTGACCATGATGGCTATCCTTGCTTGCCAAAACCTGACGCCCTGGCAGGTAACTTTCATCAGGCATCTCTGAA

Downstream sequence

ATGGTACCTAAATGAATTAGCAATAAAATGGACTTAGGCCGAGCAGTGGGGGCCTCCATTAATCTTGGGTTAATCACTAAAGAGGTGCCATTCACTTTTC