Basic Information
VIS ID
TVIS10014896
Fusion event
HBV-chr18 integration
Validated
No
Detection method
WGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2012
PubMed ID
22634754
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
HBVgp3 X protein;HBVgp4 precore/core protein
Start
1826
Orient
-
Integrated sequence
AAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTT| |TCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAAGAA
Host Sequence
Chromosome
chr18
Cytoband
q21.1
Reference genome
GRCh37/hg19
Start
45256947/47730576 (Hg38)
End
45256947/47730576 (Hg38)
Orient
-
Location type
Intergenic
Nearest miRNA
hsa-mir-1-2/Upstream/350011; hsa-mir-122/Downstream/940024;
Nearest TSS
ENST00000575820/Upstream/155980; ENST00000599498/Downstream/147719;
Nearest CpG islands
None/Target, chr18-CpG: 67/Upstream/466269, chr18-CpG: 186/Downstream/199537
Upstream sequence
CTCCTCGATGGAGAAGCTGGGAGCCTTGACAAAGAAACCTACAAACACAACGTCTCTAGCTGCTTCCAGTGGAAAAAGATAAACAATGAAAATAAAGCAG
Downstream sequence
GAGAAGGGAATCCAACTGAGCAATGATCACCGTGATGATAATACTTTATGCACACGAGCACCTGTCATCCCTCAGCCCTCATCATGCCTCCTGCCCAGTG
Reference
Sung, W. K., et al. Genome-wide survey of recurrent HBV integration in hepatocellular carcinoma. Nat Genet,2012, 44(7): 765-769.
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