Basic Information
VIS ID
TVIS10014900
Fusion event
HBV-chr5 integration
Validated
No
Detection method
WGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2012
PubMed ID
22634754
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
HBVgp4 precore/core protein
Start
1891
Orient
+
Integrated sequence
TAAATTGGTCTGCGCACCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGT| |GGCTTTGGGGCATGGACATCGACCCTTATAAAGAATTTGGAGCTACTGTGGAGTTACTCTCGTTTTTGCCTTCTGACTTCTTTCCTTCAGTACGAGATCT
Host Sequence
Chromosome
chr5
Cytoband
p13.2
Reference genome
GRCh37/hg19
Start
37812440/37812338 (Hg38)
End
37812440/37812338 (Hg38)
Orient
+
Location type
Intergenic
Fragile sites / regions
FRA5A
Nearest miRNA
hsa-mir-10397/Upstream/1664350; hsa-mir-103a-1/Downstream/745164;
Nearest TSS
ENST00000502646/Upstream/749; ENST00000503382/Downstream/22484;
Nearest CpG islands
None/Target, chr5-CpG: 87/Upstream/432784, chr5-CpG: 51/Downstream/22231
Nearby gene
GDNF(No orient, 338)
Upstream sequence
AAAATTTTATGAACTGGATGTATATATAAGTTGGTATTTATAATCTCAAAGTTATTTATAAATGAATCAGTAGAAGCCTGTTGGGTTTTTGTTTGTTTGT
Downstream sequence
agggatcactacatattttacttttttgaatgttgtctgtctccccgcaaataaaataactccaggaggacagcggtttttgctttggtcaccattagag
Reference
Sung, W. K., et al. Genome-wide survey of recurrent HBV integration in hepatocellular carcinoma. Nat Genet,2012, 44(7): 765-769.
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