Basic Information
VIS ID
TVIS10014901
Fusion event
HBV-chr5 integration
Validated
No
Detection method
WGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2012
PubMed ID
22634754
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
HBVgp3 X protein
Start
1683
Orient
-
Integrated sequence
CACTTCGCTTCACCTCTGCACGTCGCATGGAGACCACCGTGAACGCCCACCAAATATTGCCCAAGGTCTTACATAAGAGGACTCTTGGACTCTCAGCAAT| |GTCAACGACCGACCTTGAGGCATACTTCAAAGACTGTTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGC
Host Sequence
Chromosome
chr5
Cytoband
p13.2
Reference genome
GRCh37/hg19
Start
37812520/37812418 (Hg38)
End
37812520/37812418 (Hg38)
Orient
-
Location type
Intergenic
Fragile sites / regions
FRA5A
Nearest miRNA
hsa-mir-10397/Upstream/1664430; hsa-mir-103a-1/Downstream/745084;
Nearest TSS
ENST00000502646/Upstream/829; ENST00000503382/Downstream/22404;
Nearest CpG islands
None/Target, chr5-CpG: 87/Upstream/432864, chr5-CpG: 51/Downstream/22151
Nearby gene
GDNF(No orient, 258)
Upstream sequence
tttttgagtgtaagctcatgctttaggaatataacttttaaagcctttttttttccatttaattctacttggttcaatAAAGAATACTAATATAAGAGTT
Downstream sequence
tgctttggtcaccattagagccctggtgccaggaacagtgcctggcacagtgtaggcacaccataagggtttgttgaatgaataaGAACAATTTTGCAAG
Reference
Sung, W. K., et al. Genome-wide survey of recurrent HBV integration in hepatocellular carcinoma. Nat Genet,2012, 44(7): 765-769.
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