Basic Information
VIS ID
TVIS10014906
Fusion event
HBV-DPH6 integration
Validated
No
Detection method
WGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2012
PubMed ID
22634754
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
HBVgp4 precore/core protein
Start
1965
Orient
+
Integrated sequence
TCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAAGAATTTGGAGCTACTGTGGAGTTACTCTCGTTTTTGCCTTCT| |GACTTCTTTCCTTCAGTACGAGATCTTCTAGATACCGCCTCAGCTCTGTATCGGGAAGCCTTAGAGTCTCCTGAGCATTGTTCACCTCACCATACTGCAC
Host Sequence
Chromosome
chr15
Cytoband
q14
Reference genome
GRCh37/hg19
Start
35580276/35288075 (Hg38)
End
35580276/35288075 (Hg38)
Orient
+
Location type
Intronic
Target gene
DPH6
Nearest miRNA
hsa-mir-1233-1/Upstream/759704; hsa-mir-10393/Downstream/84181;
Nearest TSS
ENST00000557528/Upstream/118377; ENST00000560866/Downstream/122776;
Nearest CpG islands
None/Target, chr15-CpG: 55/Upstream/165836, chr15-CpG: 56/Downstream/257850
Upstream sequence
TAAATAAACCACGGACAATACCTGACACTGGACCTTTCATTCTTGCAATGCTATGCTGAATAAGCATGCTCCCCTTGCCTGTCTGAATTCTATATGCCCA
Downstream sequence
TTTCCAGAAATGCTGCTGCAGATAAGTTACAGTGTCATGTTCATTTTGTCAACTACATACTGATTATCCTTTCCTATCTGTAGTTTGGGAACATTATCAA
Reference
Sung, W. K., et al. Genome-wide survey of recurrent HBV integration in hepatocellular carcinoma. Nat Genet,2012, 44(7): 765-769.
Curate