Basic Information
VIS ID
TVIS10014907
Fusion event
HBV-LOC105370232 integration
Validated
No
Detection method
WGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2012
PubMed ID
22634754
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
HBVgp3 X protein;HBVgp4 precore/core protein
Start
1828
Orient
+
Integrated sequence
AGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTTC| |ACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAAGAATT
Host Sequence
Chromosome
chr13
Cytoband
q21.31
Reference genome
GRCh37/hg19
Start
63147352/62573219 (Hg38)
End
63147352/62573219 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA13B
Target gene
LOC105370232
Nearest miRNA
hsa-mir-1297/Upstream/1373339; hsa-mir-1267/Downstream/3393111;
Nearest TSS
ENST00000623511/Upstream/249562; ENST00000618134/Downstream/158961;
Nearest CpG islands
None/Target, chr13-CpG: 551/Upstream/2175308, chr13-CpG: 36/Downstream/1238367
Upstream sequence
tatattttatacattaattCCATTAGATCTGAATAAAAGAGTTAAAATAGcatcattgattgaacacttactgtaggtcaggcactattgaaagtacttc
Downstream sequence
acaggtaataattcattaaattttaaaactctgtgGggccaggcatggtggctcaagcctgtaatcccagcatttgggaggcctaggagggaggatcatg
Reference
Sung, W. K., et al. Genome-wide survey of recurrent HBV integration in hepatocellular carcinoma. Nat Genet,2012, 44(7): 765-769.
Curate