VISDB Viral Integration Site DataBase

VIS ID

TVIS10014909

Fusion event

HBV-NTRK3 integration

Validated

No

Detection method

WGS

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Normal

Reported year

2012

PubMed ID

Virus name

HBV

Reference genome

Region type

HBVgp3 X protein;HBVgp4 precore/core protein

Start

1814

Orient

+

Integrated sequence

GACTGTTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCAC| |CATGCAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGAC

Chromosome

chr15

Cytoband

q25.3

Reference genome

Start

End

88688212/88144981 (Hg38)

Orient

+

Location type

Intronic

Target gene

miRNAs that regulate target gene

hsa-mir-765 ; hsa-mir-485-3p ; hsa-mir-128-3p ; hsa-mir-9-5p ; hsa-mir-125b-5p ; hsa-mir-125a-5p ; hsa-mir-617 ; hsa-mir-345-5p ; hsa-mir-384 ; hsa-mir-330-3p ; hsa-mir-198 ; hsa-mir-625-5p ; hsa-mir-509-3p ; hsa-mir-151a-3p ; hsa-mir-185-5p ; hsa-mir-768-5p ; hsa-mir-615-3p ; hsa-mir-190a-3p ; hsa-mir-5011-5p ; hsa-mir-1277-5p ; hsa-mir-410-3p ; hsa-mir-4776-3p ; hsa-mir-192-3p

Nearest miRNA

hsa-mir-10393/Upstream/198713; hsa-mir-1179/Downstream/463126;

Nearest TSS

Nearest CpG islands

None/Target, chr15-CpG: 55/Upstream/2304097, chr15-CpG: 36/Downstream/110442

Nearest cancer related gene

NTRK3(TSG, No orient, 0)

Upstream sequence

TACAGCAGAGGTCCTTAGTGACAGAAAGAAACATGTTAAGGAATTGCTGCACACCCTCTGCCCCTTCTGTCCCTGCAGAGGGTCACTTAAACCTCACACT

Downstream sequence

TCTGGCCTGTGGCTTTCCTGGCTCCACAACACACTGAGCCCTTTCTCCTCCAGGGCCAAAATTCTTTCTTCCTGGAAATACACAACCCATCCCCACGCCC