VISDB Viral Integration Site DataBase

VIS ID

TVIS10014915

Fusion event

HBV-SLBP integration

Validated

No

Detection method

WGS

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Normal

Reported year

2012

PubMed ID

Virus name

HBV

Reference genome

Region type

HBVgp4 precore/core protein

Start

1960

Orient

+

Integrated sequence

ACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAAGAATTTGGAGCTACTGTGGAGTTACTCTCGTTTTTGC| |CTTCTGACTTCTTTCCTTCAGTACGAGATCTTCTAGATACCGCCTCAGCTCTGTATCGGGAAGCCTTAGAGTCTCCTGAGCATTGTTCACCTCACCATAC

Chromosome

chr4

Cytoband

p16.3

Reference genome

Start

End

1709025/1707298 (Hg38)

Orient

+

Location type

Intronic

Target gene

miRNAs that regulate target gene

hsa-mir-1-3p ; hsa-mir-26b-5p ; hsa-mir-3680-3p ; hsa-mir-557 ; hsa-mir-507 ; hsa-mir-450b-5p ; hsa-mir-106a-3p ; hsa-mir-3124-3p ; hsa-mir-4733-5p ; hsa-mir-4703-5p ; hsa-mir-3942-5p ; hsa-mir-548e-5p ; hsa-mir-129-5p ; hsa-mir-8064 ; hsa-mir-362-3p ; hsa-mir-329-3p ; hsa-mir-8485 ; hsa-mir-4643 ; hsa-mir-105-5p ; hsa-mir-1197 ; hsa-mir-370-3p ; hsa-mir-6893-3p ; hsa-mir-7853-5p

Nearest miRNA

hsa-mir-571/Upstream/1357046; hsa-mir-12113/Downstream/279086;

Nearest TSS

Nearest CpG islands

None/Target, chr4-CpG: 46/Upstream/22554, chr4-CpG: 188/Downstream/4242

Upstream sequence

ACTAGGTTTTCAATATATATTAATACTTACTGAATAAGTGAGGAAAGGAATAAACTAAATGAAAAGAACAGATCACTATAATTAAAAATTTAATGATTCT

Downstream sequence

agttcaagaccagcctggctaacatggtgaaacgctgtctctactaaaaatacaaaaatcagctgggtgtggtggtgggtgcctataatcccagctactc