Basic Information
VIS ID
TVIS10014920
Fusion event
HBV-chr19 integration
Validated
No
Detection method
WGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2012
PubMed ID
22634754
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
HBVgp1 Polymerase;HBVgp2 pre-S2/S;HBVgp2
Start
306
Orient
-
Integrated sequence
GGGGTTTTTCTTGTTGACAAGAATCCTCACAATACCGCAGAGTCTAGACTCGTGGTGGACTTCTCTCAATTTTCTAGGGGGAACTACCGTGTGTCTTGGC| |CAAAATTCGCAGTCCCCAACCTCCAATCACTCACCAACCTCTTGTCCTCCAACTTGTCCTGGTTATCGCTGGATGTGTCTGCGGCGTTTTATCATCTTCC
Host Sequence
Chromosome
chr19
Cytoband
q12
Reference genome
GRCh37/hg19
Start
30277557/29786650 (Hg38)
End
30277557/29786650 (Hg38)
Orient
+
Location type
Intergenic
Nearest miRNA
hsa-mir-10395/Upstream/9387296; hsa-let-7e/Downstream/5336050;
Nearest TSS
ENST00000633603/Upstream/70861; ENST00000586912/Downstream/25248;
Nearest CpG islands
None/Target, chr19-CpG: 112/Upstream/61963, chr19-CpG: 137/Downstream/24738
Nearby gene
CCNE1(No orient, 25343)
Nearest cancer related gene
CCNE1(OG, No orient, 25343)
Upstream sequence
ACATGCtttcttttttgttgtttgtttgattgtttgtttgtttctgagacagagtctcactctgtcgcccaggctggaatgcagtggcacgatctcagct
Downstream sequence
cactgcaacctccgcctcccgggttcaagcgattctcctgcctcagcctcctgagtagctaggattacaggcatgcaccaccacgcccagctaaattttt
Reference
Sung, W. K., et al. Genome-wide survey of recurrent HBV integration in hepatocellular carcinoma. Nat Genet,2012, 44(7): 765-769.
Curate