Basic Information
VIS ID
TVIS10014925
Fusion event
HBV-chr1 integration
Validated
No
Detection method
WGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2012
PubMed ID
22634754
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
HBVgp1 Polymerase;HBVgp4 precore/core protein
Start
2314
Orient
+
Integrated sequence
ATTTCTTGTCTCACTTTTGGAAGAGAAACAGTTATAGAGTATTTGGTGTCTTTCGGAGTGTGGATTCGCACTCCTCCAGCTTATAGACCACCAAATGCCC| |CTATCCTATCAACACTTCCGGAGACTACTGTTGTTAGACGACGAGGCAGGTCCCCTAGAAGAAGAACTCCCTCGCCTCGCAGACGAAGGTCTCAATCGCC
Host Sequence
Chromosome
chr1
Cytoband
q31.3
Reference genome
GRCh37/hg19
Start
195133641/195164511 (Hg38)
End
195133641/195164511 (Hg38)
Orient
+
Location type
Intergenic
Fragile sites / regions
FRA1K
Nearest miRNA
hsa-mir-101-1/Upstream/2027928; hsa-mir-1182/Downstream/1417902;
Nearest TSS
ENST00000473358/Upstream/813568; ENST00000496761/Downstream/896562;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/2042417, chr1-CpG: 24/Downstream/1444067
Upstream sequence
ACAACCGATTAAGTCTTATTAAAGGCATGACTTATGAATTAGTCCAGAGTGGCAAGTGTCAGAAGTGGGGAAGAAACAAAGATTGTGAAAAATATTTAGA
Downstream sequence
GAGAGAGATAGGAAAGAAAATAAAACATCTGGTCAAATTAAAAATACATTTTATCTCTTTGTACTGAATTATCTATGGAAATAATGATTCAAGCTACAAT
Reference
Sung, W. K., et al. Genome-wide survey of recurrent HBV integration in hepatocellular carcinoma. Nat Genet,2012, 44(7): 765-769.
Curate