Basic Information
VIS ID
TVIS10014926
Fusion event
HBV-chr4 integration
Validated
No
Detection method
WGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2012
PubMed ID
22634754
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
HBVgp1 Polymerase
Start
2719
Orient
+
Integrated sequence
AAGAAGATTGCAATTGATTATGCCTGCCAGGTTTTATCCAAAGGTTACCAAATATTTACCATTGGATAAGGGTATTAAACCTTATTATCCAGAACATCTA| |GTTAATCATTACTTCCAAACTAGACACTATTTACACACTCTATGGAAGGCGGGTATATTATATAAGAGAGAAACAACACATAGCGCCTCATTTTGTGGGT
Host Sequence
Chromosome
chr4
Cytoband
q32.3
Reference genome
GRCh37/hg19
Start
168925874/168004723 (Hg38)
End
168925874/168004723 (Hg38)
Orient
+
Location type
Intergenic
Nearest miRNA
hsa-mir-12113/Upstream/2618386; hsa-mir-1305/Downstream/3181461;
Nearest TSS
ENST00000502981/Upstream/695934; ENST00000503003/Downstream/87792;
Nearest CpG islands
None/Target, chr4-CpG: 46/Upstream/2130534, chr4-CpG: 27/Downstream/313675
Upstream sequence
gatggcctgacttcaggagagataacccaaccttcctgtcttctctctgctgagagctgtttcaatgctcaataaaattatctgcccttaccacccttca
Downstream sequence
TGGAAAGAGTAGGCCAAGAAAGCAAAATTTAGAAAAAACATTAGAATCCAATTAGAAAAATCACAGGTGATTAAAAAATAAAAGGCAAAAACAGGCTTTA
Reference
Sung, W. K., et al. Genome-wide survey of recurrent HBV integration in hepatocellular carcinoma. Nat Genet,2012, 44(7): 765-769.
Curate