Basic Information
VIS ID
TVIS10014928
Fusion event
HBV-chr12 integration
Validated
No
Detection method
WGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2012
PubMed ID
22634754
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
HBVgp4 precore/core protein
Start
2027
Orient
+
Integrated sequence
TTGGAGCTACTGTGGAGTTACTCTCGTTTTTGCCTTCTGACTTCTTTCCTTCAGTACGAGATCTTCTAGATACCGCCTCAGCTCTGTATCGGGAAGCCTT| |AGAGTCTCCTGAGCATTGTTCACCTCACCATACTGCACTCAGGCAAGCAATTCTTTGCTGGGGGGAACTAATGACTCTAGCTACCTGGGTGGGTGTTAAT
Host Sequence
Chromosome
chr12
Cytoband
q21.33
Reference genome
GRCh37/hg19
Start
89630634/89236857 (Hg38)
End
89630634/89236857 (Hg38)
Orient
-
Location type
Intergenic
Fragile sites / regions
FRA12B
Nearest miRNA
hsa-let-7i/Upstream/2491708; hsa-mir-1178/Downstream/5324932;
Nearest TSS
ENST00000382841/Upstream/217178; ENST00000611513/Downstream/72696;
Nearest CpG islands
None/Target, chr12-CpG: 104/Upstream/655968, chr12-CpG: 248/Downstream/114534
Nearby gene
LOC105378255(-6847) ;
Upstream sequence
GTTTGAATTATTAGTGCACATCCAGGAAAAACCCAGACCTCACAGACAGGAGTGATTGAGGCACCAACACACAACAACACTACCGTGATGTGATGTCAAG
Downstream sequence
AAACTATTCCAGGTCACTTATGCAAGTGACAGAAAAGTCACCCAAACAAACATATAAAGAAACATGGCAGTCTCTGTGCAGCATTTAAGAATCCACATTG
Reference
Sung, W. K., et al. Genome-wide survey of recurrent HBV integration in hepatocellular carcinoma. Nat Genet,2012, 44(7): 765-769.
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