Basic Information
VIS ID
TVIS10014929
Fusion event
HBV-chr19 integration
Validated
No
Detection method
WGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2012
PubMed ID
22634754
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
HBVgp1 Polymerase;HBVgp3 X protein
Start
1561
Orient
-
Integrated sequence
CTTCTCGGGGTCGCTTGGGACTCTCTCGTCCCCTTCTCCGTCTGCCGTTCCGACCGACCACGGGGCGCACCTCTCTTTACGCGGACTCCCCGTCTGTGCC| |TTCTCATCTGCCGGACCGTGTGCACTTCGCTTCACCTCTGCACGTCGCATGGAGACCACCGTGAACGCCCACCAAATATTGCCCAAGGTCTTACATAAGA
Host Sequence
Chromosome
chr19
Cytoband
q13.42
Reference genome
GRCh37/hg19
Start
54910801/54399196 (Hg38)
End
54910801/54399196 (Hg38)
Orient
+
Location type
Intergenic
Fragile sites / regions
FRA19A
Nearest miRNA
hsa-let-7e/Upstream/117016; hsa-mir-10394/Downstream/246113;
Nearest TSS
ENST00000633603/Upstream/28638; ENST00000462769/Downstream/16023;
Nearest CpG islands
None/Target, chr19-CpG: 112/Upstream/191689, chr19-CpG: 54/Downstream/16033
Nearby gene
TTYH1(No orient, 15803)
Upstream sequence
aaagtatgcaaactaagcaggcaaaaagagtctgctaacagaatgcaagtcacacaatcatccttaaaaggacgggattacatgatgctataaataccag
Downstream sequence
gaggtgaggattattggggaccatctgggaggctgcctaccacaCCGCACAAGGCAAACCTTATGAATATGTATGGATTATATAGGTtgctttcaggctt
Reference
Sung, W. K., et al. Genome-wide survey of recurrent HBV integration in hepatocellular carcinoma. Nat Genet,2012, 44(7): 765-769.
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