Basic Information
VIS ID
TVIS10014930
Fusion event
HBV-chr19 integration
Validated
No
Detection method
WGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2012
PubMed ID
22634754
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
HBVgp1 Polymerase;HBVgp3 X protein
Start
1543
Orient
+
Integrated sequence
TGAATCCTGCGGACGACCCTTCTCGGGGTCGCTTGGGACTCTCTCGTCCCCTTCTCCGTCTGCCGTTCCGACCGACCACGGGGCGCACCTCTCTTTACGC| |GGACTCCCCGTCTGTGCCTTCTCATCTGCCGGACCGTGTGCACTTCGCTTCACCTCTGCACGTCGCATGGAGACCACCGTGAACGCCCACCAAATATTGC
Host Sequence
Chromosome
chr19
Cytoband
q13.42
Reference genome
GRCh37/hg19
Start
54911045/54399440 (Hg38)
End
54911045/54399440 (Hg38)
Orient
-
Location type
Intergenic
Fragile sites / regions
FRA19A
Nearest miRNA
hsa-let-7e/Upstream/117260; hsa-mir-10394/Downstream/245869;
Nearest TSS
ENST00000633603/Upstream/28882; ENST00000462769/Downstream/15779;
Nearest CpG islands
None/Target, chr19-CpG: 112/Upstream/191933, chr19-CpG: 54/Downstream/15789
Nearby gene
TTYH1(No orient, 15559)
Upstream sequence
caccccagcaggtgtggcttgcttgttttaagggagcagagacagagggttccttatatcccacagccaagcccttacaggcacagcagggcagctgctt
Downstream sequence
aaggtggagagggagtctaaccggttttcttaccatgcttagggcagaaaacataatctctattttgccatgtaagactcaccactgagcagtccctctc
Reference
Sung, W. K., et al. Genome-wide survey of recurrent HBV integration in hepatocellular carcinoma. Nat Genet,2012, 44(7): 765-769.
Curate