Basic Information
VIS ID
TVIS10014931
Fusion event
HBV-chr8 integration
Validated
No
Detection method
WGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2012
PubMed ID
22634754
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
HBVgp4 precore/core protein
Start
1910
Orient
+
Integrated sequence
GCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACAT| |CGACCCTTATAAAGAATTTGGAGCTACTGTGGAGTTACTCTCGTTTTTGCCTTCTGACTTCTTTCCTTCAGTACGAGATCTTCTAGATACCGCCTCAGCT
Host Sequence
Chromosome
chr8
Cytoband
p22
Reference genome
GRCh37/hg19
Start
13767554/13910045 (Hg38)
End
13767554/13910045 (Hg38)
Orient
+
Location type
Intergenic
Nearest miRNA
hsa-mir-124-1/Upstream/1182741; hsa-mir-10400/Downstream/943393;
Nearest TSS
ENST00000518652/Upstream/60936; ENST00000527110/Downstream/251252;
Nearest CpG islands
None/Target, chr8-CpG: 109/Upstream/633254, chr8-CpG: 87/Downstream/1326683
Nearby gene
LOC100421673(-261) ;
Upstream sequence
gagaattgcttgaacccaggaggcagaggttgcagtgagccgagatcgttccactgcactccagcctgggtgacagaaaaaaaaactttgtctaaaataa
Downstream sequence
ATATTTCCTAATCATCTTGATTAAGTAACATCATCTAATTAAGTAACATCTAAAACTGGAAACAAAAATAGCAGGATAAGGATGTTAGTTGTATTTGTGG
Reference
Sung, W. K., et al. Genome-wide survey of recurrent HBV integration in hepatocellular carcinoma. Nat Genet,2012, 44(7): 765-769.
Curate