Basic Information
VIS ID
TVIS10014944
Fusion event
HBV-chr8 integration
Validated
No
Detection method
WGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2012
PubMed ID
22634754
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
HBVgp1 Polymerase
Start
2833
Orient
-
Integrated sequence
CCAAACTAGACACTATTTACACACTCTATGGAAGGCGGGTATATTATATAAGAGAGAAACAACACATAGCGCCTCATTTTGTGGGTCACCATATTCTTGG| |GAACAAGATCTACAGCATGGGGCAGAATCTTTCCACCAGCAATCCTCTGGGATTCTTTCCCGACCACCAGTTGGATCCAGCCTTCAGAGCAAACACCGCA
Host Sequence
Chromosome
chr8
Cytoband
p23.1
Reference genome
GRCh37/hg19
Start
12270963/12413454 (Hg38)
End
12270963/12413454 (Hg38)
Orient
+
Nearest miRNA
hsa-mir-124-1/Upstream/1378152; hsa-mir-10400/Downstream/305678;
Nearest TSS
ENST00000518652/Upstream/627; ENST00000602979/Downstream/22844;
Nearest CpG islands
None/Target, chr8-CpG: 109/Upstream/51047, chr8-CpG: 113/Downstream/22430
Nearby gene
FAM66A(-2453) ; ALG1L12P(+1067) ;
Upstream sequence
GGAGTTCTACTGACCATGGAGGTCCTGAATTTAAACCTTCTGTTAGAATTGCAAGGAAGTGGAGCATTTATTCATTAATTTGttcactccctgcaaacac
Downstream sequence
agaaagagagatcagactgtcactgtgtctatgtcgaaagggaagacataagagactctattttgaaaaggacctgtactttaaacaattgctttgctga
Reference
Sung, W. K., et al. Genome-wide survey of recurrent HBV integration in hepatocellular carcinoma. Nat Genet,2012, 44(7): 765-769.
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