Basic Information
VIS ID
TVIS10014946
Fusion event
HBV-chr13 integration
Validated
No
Detection method
WGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2012
PubMed ID
22634754
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
HBVgp1 Polymerase;HBVgp2 pre-S2/S;HBVgp2
Start
752
Orient
-
Integrated sequence
CCTCAGCCCGTTTCTCCTGGCTCAGTTTACTAGTGCCATTTGTTCAGTGGTTCGTAGGGCTTTCCCCCACTGTTTGGCTTTCAGTTATATGGATGATGTG| |GTATTGGGGGCCAAGTCTGTACAGCATCTTGAGTCCCTTTTTACCGCTGTTACCAATTTTCTTTTGTCTTTGGGTATACATTTAAACCCTAACAAAACAA
Host Sequence
Chromosome
chr13
Cytoband
q12.11
Reference genome
GRCh37/hg19
Start
22948394/22374255 (Hg38)
End
22948394/22374255 (Hg38)
Orient
-
Nearest miRNA
hsa-mir-4499/Upstream/1940409; hsa-mir-1267/Downstream/1788161;
Nearest TSS
ENST00000623511/Upstream/163970; ENST00000575845/Downstream/542114;
Nearest CpG islands
None/Target, chr13-CpG: 551/Upstream/698639, chr13-CpG: 30/Downstream/322186
Upstream sequence
ctgaccagtgaaatgtgggcaattataatgtgtgcatttccagggctggcctctcctggaaacatctagaggaagaatccacatccctgcaggactccca
Downstream sequence
ggttttaggaggtggcaaaaccatacataaaagtatcctgaatccctgcatcatttcatggtggatgttgtcaaaggatgccactcacactggaacacct
Reference
Sung, W. K., et al. Genome-wide survey of recurrent HBV integration in hepatocellular carcinoma. Nat Genet,2012, 44(7): 765-769.
Curate