Basic Information
VIS ID
TVIS10014951
Fusion event
HBV-chr11 integration
Validated
No
Detection method
WGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2012
PubMed ID
22634754
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
HBVgp3 X protein
Start
1798
Orient
-
Integrated sequence
TGAGGCATACTTCAAAGACTGTTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTG| |GTCTGCGCACCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTG
Host Sequence
Chromosome
chr11
Cytoband
q13.3
Reference genome
GRCh37/hg19
Start
69687299/69872531 (Hg38)
End
69687299/69872531 (Hg38)
Orient
+
Location type
Intergenic
Fragile sites / regions
FRA11H ; FRA11A
Nearest miRNA
hsa-mir-10392/Upstream/789273; hsa-let-7a-2/Downstream/411424;
Nearest TSS
ENST00000527297/Upstream/53507; ENST00000534086/Downstream/38463;
Nearest CpG islands
None/Target, chr11-CpG: 30/Upstream/3679, chr11-CpG: 18/Downstream/19479
Upstream sequence
ccacctgaacccatcatgcccacctggacccatcacgcccacctggacccatcacgcccacctggacccatcacgcccacctggacccatcacgcccacc
Downstream sequence
tagacccatcacacccacctggacccatcacacccacctggatccatcaaacccacctggacccatcacatccaccTGGATCCATCAAACCCACCTGGAC
Reference
Sung, W. K., et al. Genome-wide survey of recurrent HBV integration in hepatocellular carcinoma. Nat Genet,2012, 44(7): 765-769.
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