Basic Information
VIS ID
TVIS10014952
Fusion event
HBV-chrX integration
Validated
No
Detection method
WGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2012
PubMed ID
22634754
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
HBVgp1 Polymerase;HBVgp2 pre-S2/S;HBVgp2
Start
782
Orient
-
Integrated sequence
TAGTGCCATTTGTTCAGTGGTTCGTAGGGCTTTCCCCCACTGTTTGGCTTTCAGTTATATGGATGATGTGGTATTGGGGGCCAAGTCTGTACAGCATCTT| |GAGTCCCTTTTTACCGCTGTTACCAATTTTCTTTTGTCTTTGGGTATACATTTAAACCCTAACAAAACAAAGAGATGGGGTTACTCTCTAAATTTTATGG
Host Sequence
Chromosome
chrX
Reference genome
GRCh37/hg19
Start
144158529/144158529 (Hg38)
End
144158529/144158529 (Hg38)
Orient
-
Location type
Intergenic
Fragile sites / regions
FRAXA
Nearest miRNA
hsa-let-7f-2/Upstream/3232298; hsa-mir-105-1/Downstream/1834221;
Nearest CpG islands
None/Target, chrX-CpG: 62/Upstream/523403, chrX-CpG: 63/Downstream/1472374
Upstream sequence
GGGATGAAGAGTAGGAAGGGGAGAGAGAAGTGAGCAAACATGGATGTACTATGTGTTTTTCCTTAAGAATGGTGAAGTTGTTTTTTTTTTTTAAAAAAAG
Downstream sequence
ctttaagggtaagtttgtcagagtttggaatcatttgagctccttggaacgtagttctcatctccaactcctgggatactatatatccctccagtagata
Reference
Sung, W. K., et al. Genome-wide survey of recurrent HBV integration in hepatocellular carcinoma. Nat Genet,2012, 44(7): 765-769.
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