VISDB Viral Integration Site DataBase

VIS ID

TVIS10014953

Fusion event

HBV-FN1 integration

Validated

Yes

Detection method

PCR and Sanger sequencing

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Good

Reported year

2012

PubMed ID

Virus name

HBV

Reference genome

Region type

HBVgp3 X protein;HBVgp4 precore/core protein

Start

1708

End

1823

Orient

-

Integrated sequence

TTCAAAGACTGTTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTT

Chromosome

chr2

Cytoband

q35

Reference genome

Start

End

216297478/215432755 (Hg38)

Orient

+

Location type

Intronic

Target gene

miRNAs that regulate target gene

hsa-mir-200c-3p ; hsa-mir-200b-3p ; hsa-mir-1-3p ; hsa-let-7g-5p ; hsa-mir-26b-5p ; hsa-mir-615-3p ; hsa-mir-218-5p ; hsa-mir-140-3p

Nearest miRNA

hsa-mir-10b/Upstream/1673943; hsa-mir-1244-1/Downstream/2467758;

Nearest TSS

Nearest CpG islands

None/Target, chr2-CpG: 135/Upstream/119693, chr2-CpG: 43/Downstream/2789

Upstream sequence

ACAGATTTTTTTTTTTGGTCTCATATTCCACCCATGGTAGGTACTTAGGTTGGCTAAAGTAGAGACACAGACAACAGCTTTCCCATCAGAGACAGGGGAA

Downstream sequence

AGTTCCTTAGCAAACTCTATTGGGTTAATAATTTTGTATTATCCCTAGGAATAGTGACATCTGCTTCCTGGGTATAACCTACTGGTCACCAAGAAACCAG

Target sequence

ACGTTAACAGGTCTGGTCACTTGGAGTCAATTCAGTTAAGTGTCTTGCTTAGAACACAATGGAAAACCACAGAGAAATCTGGATGGCAAGGAAGAGGTCATGAATCCTGCTTTCCCAGAGAGATCACAGGAAATTGGGTCCTAAGCAGAAAAGAAAGGCTGGGAGGCTTGGTCTTCACTCATACACAGCAGGCTAAGACTGAGACTAATTCAGTGAAAAGGCCACATCAGGCACAGCACTCCAGCTTTTGGGAGC