Basic Information
VIS ID
TVIS10014959
Fusion event
HBV-chr8 integration
Validated
No
Detection method
WGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2012
PubMed ID
22634754
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
HBVgp1 Polymerase;HBVgp2 pre-S2/S
Start
113
Orient
+
Integrated sequence
TCCACCAAACTCTGCAAGATCCCAGAGTGAGAGGCCTGTATTTCCCTGCTGGTGGCTCCAGTTCAGGAACAGTAAACCCTGTTCTGACTACTGCCTCTCC| |CTTATCGTCAATCTTCTCGAGGATTGGGGACCCTGCGCTGAACATGGAGAACATCACATCAGGATTCCTAGGACCCCTTCTCGTGTTACAGGCGGGGTTT
Host Sequence
Chromosome
chr8
Cytoband
q21.3
Reference genome
GRCh37/hg19
Start
91482828/90470600 (Hg38)
End
91482828/90470600 (Hg38)
Orient
-
Location type
Intergenic
Nearest miRNA
hsa-mir-12123/Upstream/10229127; hsa-mir-10400/Downstream/734885;
Nearest TSS
ENST00000518652/Upstream/249062; ENST00000519233/Downstream/135465;
Nearest CpG islands
None/Target, chr8-CpG: 109/Upstream/468562, chr8-CpG: 159/Downstream/174561
Upstream sequence
GCTCACTTTGCACCATAGCCCAGAGCCAGGGAAGCTCTGCTGGGGGTGTGGGGCGTGGGAAATAATAATCTAAGACTATTGATATGAGCTGAATCTTGAT
Downstream sequence
TCATTTTTCTTCCTCCTTTAGCTTAGAAGCCTAGAAGGTTGATGATTCTTCTTAGAATGAAACTATCCTCCGAAGGTTACATTTCTAGGATTCAATTTCT
Reference
Sung, W. K., et al. Genome-wide survey of recurrent HBV integration in hepatocellular carcinoma. Nat Genet,2012, 44(7): 765-769.
Curate