Basic Information
VIS ID
TVIS10014969
Fusion event
HBV-SEPTIN11 integration
Validated
No
Detection method
WGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2012
PubMed ID
22634754
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
HBVgp4 precore/core protein
Start
1872
Orient
-
Integrated sequence
TACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCC| |TCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAAGAATTTGGAGCTACTGTGGAGTTACTCTCGTTTTTGCCTTCTGACTTCT
Host Sequence
Chromosome
chr4
Cytoband
q21.1
Reference genome
GRCh37/hg19
Start
77945228/77024075 (Hg38)
End
77945228/77024075 (Hg38)
Orient
+
Location type
Intronic
Target gene
SEPTIN11
miRNAs that regulate target gene
hsa-mir-155-5p ; hsa-mir-186-5p ; hsa-mir-101-3p ; hsa-mir-222-3p ; hsa-mir-17-5p
Nearest miRNA
hsa-mir-12113/Upstream/448449; hsa-mir-1243/Downstream/5729262;
Nearest TSS
ENST00000502981/Upstream/3543; ENST00000502401/Downstream/4642;
Nearest CpG islands
None/Target, chr4-CpG: 46/Upstream/73106, chr4-CpG: 106/Downstream/51193
Upstream sequence
GAACAGAAACAGTCTCTATTCATCCACCTCACTGCTCATGAGAATTCTAGACATCTATGAAGAAACCGAGACATTTTGAAATAGAAGGTAAAGGAGAAGA
Downstream sequence
GAGTGACCTCTAACACCAAGTCTAGTAAGAGGCAGTGCCACTGTGTATGTTACACAGTGTGAGGCAAAAGGAGGAGTAGCGCGCGCACAGAAACGCCGTA
Reference
Sung, W. K., et al. Genome-wide survey of recurrent HBV integration in hepatocellular carcinoma. Nat Genet,2012, 44(7): 765-769.
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