Basic Information
VIS ID
TVIS10014972
Fusion event
HBV-chr12 integration
Validated
No
Detection method
WGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2012
PubMed ID
22634754
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
HBVgp1 Polymerase
Start
1239
Orient
+
Integrated sequence
AACCTTTACCCCGTTGCCCGGCAACGGCCAGGTCTGTGCCAAGTGTTTGCTGACGCAACCCCCACTGGCTGGGGCTTGGTCATGGGCCATCAGCGCATGC| |GTGGAACCTTTTCGGCTCCTCTGCCGATCCATACTGCGGAACTCCTAGCCGCTTGTTTTGCTCGCAGCAGGTCTGGAGCAAACATTATCGGGACTGATAA
Host Sequence
Chromosome
chr12
Cytoband
q13.3
Reference genome
GRCh37/hg19
Start
57308159/56914375 (Hg38)
End
57308159/56914375 (Hg38)
Orient
+
Location type
Intergenic
Nearest miRNA
hsa-mir-1244-3/Upstream/2577061; hsa-let-7i/Downstream/280129;
Nearest TSS
ENST00000382841/Upstream/128446; ENST00000622922/Downstream/20030;
Nearest CpG islands
None/Target, chr12-CpG: 104/Upstream/161826, chr12-CpG: 79/Downstream/91709
Upstream sequence
gcccaccttggcctcccaaagtgctgggattatgggtgtgagccaccatgcctggccCCTTCTAGTTTTATAAATTATGTATttataattgtattattaa
Downstream sequence
tatgtttatattatagaaactatattataaatattatttaaatacaatatcaatattaaatacaataatatttatattatttaaattatatttaataata
Reference
Sung, W. K., et al. Genome-wide survey of recurrent HBV integration in hepatocellular carcinoma. Nat Genet,2012, 44(7): 765-769.
Curate