Basic Information
VIS ID
TVIS10014973
Fusion event
HBV-chr13 integration
Validated
No
Detection method
WGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2012
PubMed ID
22634754
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
HBVgp4 precore/core protein
Start
1937
Orient
-
Integrated sequence
TAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAAGAATTTGGAGCTAC| |TGTGGAGTTACTCTCGTTTTTGCCTTCTGACTTCTTTCCTTCAGTACGAGATCTTCTAGATACCGCCTCAGCTCTGTATCGGGAAGCCTTAGAGTCTCCT
Host Sequence
Chromosome
chr13
Cytoband
q22.1
Reference genome
GRCh37/hg19
Start
75213064/74638927 (Hg38)
End
75213064/74638927 (Hg38)
Orient
-
Location type
Intergenic
Fragile sites / regions
FRA13E
Nearest miRNA
hsa-mir-1297/Upstream/8420603; hsa-mir-1267/Downstream/3059085;
Nearest TSS
ENST00000623511/Upstream/82391; ENST00000434832/Downstream/611553;
Nearest CpG islands
None/Target, chr13-CpG: 551/Upstream/503246, chr13-CpG: 197/Downstream/841789
Upstream sequence
AGGTTATATTTCTGTTCAAAAAAGGCTTATCAGTATGaatatattaatttatttcattataattaattatGCACAAATATACATGAGTATATTTTCTCTA
Downstream sequence
GAGTGAGGAAATAATAACAGTTATCACCTGAAAAAGTTATAtacaaacatatattttgagagagaccacattcacatcacttttattacagcatattgtt
Reference
Sung, W. K., et al. Genome-wide survey of recurrent HBV integration in hepatocellular carcinoma. Nat Genet,2012, 44(7): 765-769.
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