Basic Information
VIS ID
TVIS10014974
Fusion event
HBV-chr13 integration
Validated
No
Detection method
WGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2012
PubMed ID
22634754
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
HBVgp3 X protein
Start
1722
Orient
-
Integrated sequence
TGAACGCCCACCAAATATTGCCCAAGGTCTTACATAAGAGGACTCTTGGACTCTCAGCAATGTCAACGACCGACCTTGAGGCATACTTCAAAGACTGTTT| |GTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAAC
Host Sequence
Chromosome
chr13
Cytoband
q22.1
Reference genome
GRCh37/hg19
Start
75214806/74640669 (Hg38)
End
75214806/74640669 (Hg38)
Orient
+
Location type
Intergenic
Fragile sites / regions
FRA13E
Nearest miRNA
hsa-mir-1297/Upstream/8422345; hsa-mir-1267/Downstream/3057343;
Nearest TSS
ENST00000623511/Upstream/84133; ENST00000434832/Downstream/609811;
Nearest CpG islands
None/Target, chr13-CpG: 551/Upstream/504988, chr13-CpG: 197/Downstream/840047
Nearby gene
LOC105370260(+8736) ;
Upstream sequence
CTTCTAATTAATATCCAGGGAACAGTTTAGGAACTGAGAACATCTTGTTTAACCCACTCAAGTCACACTTAAGAAAACCTTGAAGGTTTTCACCTTGTTT
Downstream sequence
GGATGCTATATAAGAATGCAATTCAGATTCAAAAAGTGTGTTCTGAAATCTTACTTGGAACACTTTCACTTTGTAAAAAGAATCTTTCATTGTATATGAG
Reference
Sung, W. K., et al. Genome-wide survey of recurrent HBV integration in hepatocellular carcinoma. Nat Genet,2012, 44(7): 765-769.
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