Basic Information
VIS ID
TVIS10014976
Fusion event
HBV-chr18 integration
Validated
No
Detection method
WGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2012
PubMed ID
22634754
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
HBVgp1 Polymerase
Start
2637
Orient
+
Integrated sequence
CATCTTTTCCTAATATACATTTACACCAAGACATTATCAAAAAATGTGAACAGTTTGTAGGCCCACTCACAGTTAATGAGAAAAGAAGATTGCAATTGAT| |TATGCCTGCCAGGTTTTATCCAAAGGTTACCAAATATTTACCATTGGATAAGGGTATTAAACCTTATTATCCAGAACATCTAGTTAATCATTACTTCCAA
Host Sequence
Chromosome
chr18
Cytoband
q22.1
Reference genome
GRCh37/hg19
Start
63841663/66174426 (Hg38)
End
63841663/66174426 (Hg38)
Orient
+
Location type
Intergenic
Nearest miRNA
hsa-mir-1-2/Upstream/7723268; hsa-mir-5011/Downstream/907158;
Nearest TSS
ENST00000575820/Upstream/253484; ENST00000581951/Downstream/397745;
Nearest CpG islands
None/Target, chr18-CpG: 67/Upstream/423022, chr18-CpG: 83/Downstream/1341574
Upstream sequence
GTAAATGTTTGGTAAATGAGTTTTTTTGTGAATCTCaaaaaataaaaataaaaaaaaCAGCTGTTGCTTGTTTTTGCTACTAATAATATTTACTTGTCTC
Downstream sequence
CAAGAATCTTAGCTTTTAAGAAAGATAGAGGAATAAAGGGCACTGAATTGAGAGAACTCTCTACAGAAGATAAGTTGAATGTTTGTATCTTCTTAATATC
Reference
Sung, W. K., et al. Genome-wide survey of recurrent HBV integration in hepatocellular carcinoma. Nat Genet,2012, 44(7): 765-769.
Curate