VISDB Viral Integration Site DataBase

VIS ID

TVIS10014980

Fusion event

HBV-CCNE1 integration

Validated

Yes

Detection method

PCR and Sanger sequencing

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Good

Reported year

2012

PubMed ID

Virus name

HBV

Reference genome

Region type

HBVgp1 Polymerase

Start

1053

End

1059

Orient

+

Integrated sequence

TGATGCC

Chromosome

chr19

Cytoband

q12

Reference genome

Start

End

30303328/29812585 (Hg38)

Orient

+

Location type

Promoter

Target gene

miRNAs that regulate target gene

hsa-mir-15b-5p ; hsa-mir-503-5p ; hsa-mir-424-5p ; hsa-mir-16-5p ; hsa-mir-15a-5p ; hsa-mir-107 ; hsa-mir-185-5p ; hsa-mir-103a-3p ; hsa-mir-26b-5p ; hsa-mir-26a-5p ; hsa-mir-16-1-3p ; hsa-mir-195-5p ; hsa-mir-215-5p ; hsa-mir-192-5p ; hsa-mir-151a-3p ; hsa-mir-342-5p ; hsa-mir-125b-5p ; hsa-mir-92a-3p ; hsa-mir-383-3p ; hsa-mir-497-5p ; hsa-mir-4524a-5p ; hsa-mir-4694-3p ; hsa-mir-4524b-5p ; hsa-mir-6838-5p ; hsa-mir-7-5p ; hsa-mir-4477a ; hsa-mir-524-5p ; hsa-mir-520d-5p ; hsa-mir-5191 ; hsa-mir-646 ; hsa-mir-25-5p ; hsa-mir-30c-2-3p ; hsa-mir-144-5p ; hsa-mir-892b

Nearest miRNA

hsa-mir-10395/Upstream/9413067; hsa-let-7e/Downstream/5310115;

Nearest TSS

Nearest CpG islands

chr19-CpG: 137/Target, None/Upstream, None/Downstream

Nearest cancer related gene

CCNE1(OG, No orient, 0)

Upstream sequence

CCCGCGGCCTGACCCCGCCGCCGCCTCACCCCGCGCCGCCCCGCAGGCCTCAGGCCGGAGCAGCCCCATCATGCCGAGGGAGCGCAGGGAGCGGTGAGTG

Downstream sequence

CCGCCATCGGCCATCTTCCTGGCTCGCCCGGCCGCCCGCGCGCAAAGGGGGAAGGGGTACTGGGCCCGCGGCCTGACCCCGCCGCCGCCTCACCCCGCGC

Target sequence

CCGCCATCGGCCATCTTCCTGGCTCGCCCGGCCGCCCGCGCGCAAAGGGGGAAGGGGTACTGGGCCCGCGGCCTGACCCCGCCGCCGCCTCACCCCGCGCCGCCCCGCAGGCCTCAGGCCGGAGCAGCCCCATCATGCCGAGGGAGCGCAGGGAGCGGTGAGTG