VISDB Viral Integration Site DataBase

VIS ID

TVIS10014981

Fusion event

HBV-CCNE1 integration

Validated

Yes

Detection method

PCR and Sanger sequencing

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Good

Reported year

2012

PubMed ID

Virus name

HBV

Reference genome

Region type

HBVgp3 X protein;HBVgp4 precore/core protein

Start

1819

End

1383

Orient

-

Integrated sequence

TAGGCTGTGCTGCCAACTGGATCCTGCGCGGGACGTCCTTTGTTTACGTCCCGTCGGCGCTGAATCCTGCGGACGACCCTTCTCGGGGTCGCTTGGGACTCTCTCGTCCCCTTCTCCGTCTGCCGTTCCGACCGACCACGGGGCGCACCTCTCTTTACGCGGACTCCCCGTCTGTGCCTTCTCATCTGCCGGACCGTGTGCACTTCGCTTCACCTCTGCACGTCGCATGGAGACCACCGTGAACGCCCACCAAAT

Chromosome

chr19

Cytoband

q12

Reference genome

Start

End

30304153/29813246 (Hg38)

Orient

-

Location type

Promoter

Target gene

miRNAs that regulate target gene

hsa-mir-15b-5p ; hsa-mir-503-5p ; hsa-mir-424-5p ; hsa-mir-16-5p ; hsa-mir-15a-5p ; hsa-mir-107 ; hsa-mir-185-5p ; hsa-mir-103a-3p ; hsa-mir-26b-5p ; hsa-mir-26a-5p ; hsa-mir-16-1-3p ; hsa-mir-195-5p ; hsa-mir-215-5p ; hsa-mir-192-5p ; hsa-mir-151a-3p ; hsa-mir-342-5p ; hsa-mir-125b-5p ; hsa-mir-92a-3p ; hsa-mir-383-3p ; hsa-mir-497-5p ; hsa-mir-4524a-5p ; hsa-mir-4694-3p ; hsa-mir-4524b-5p ; hsa-mir-6838-5p ; hsa-mir-7-5p ; hsa-mir-4477a ; hsa-mir-524-5p ; hsa-mir-520d-5p ; hsa-mir-5191 ; hsa-mir-646 ; hsa-mir-25-5p ; hsa-mir-30c-2-3p ; hsa-mir-144-5p ; hsa-mir-892b

Nearest miRNA

hsa-mir-10395/Upstream/9413251; hsa-let-7e/Downstream/5309454;

Nearest TSS

Nearest CpG islands

chr19-CpG: 137/Target, None/Upstream, None/Downstream

Nearest cancer related gene

CCNE1(OG, No orient, 0)

Upstream sequence

CCGCCTCACCCCGCGCCGCCCCGCAGGCCTCAGGCCGGAGCAGCCCCATCATGCCGAGGGAGCGCAGGGAGCGGTGAGTGCCCGCGCCGcggggccggac

Downstream sequence

GGCACCGTCTGAGATTACAGATATGTGCCTAGCCTGGAagaaccagaatggacatcacagtattcagtcctccccttctgcccaggaggaaactgagact

Target sequence

gggacgggacgggacgggacgggTGGCGTGGGGGAGGGGCGGCCGCGGGTGCTCACCCGGCCCGGTGCCACCCGGGTCCACAGGGATGCGAAGGAGCGGGACACCATGAAGGAGGACGGCGGCGCGGAGTTCTCGGCTCGCTCCAGGAAGAGGAAGGCAAACGTGACCGTTGTGAGTACAAAAGAGACAGGTTGGGGAGCATCCCCCCCATCTCACCTGGGTACCCGACTTGGCTCTGCCTACGGGGGCGGGGGT