Basic Information
VIS ID
TVIS10014982
Fusion event
HBV-chr20 integration
Validated
No
Detection method
WGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2012
PubMed ID
22634754
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
HBVgp3 X protein
Start
1698
Orient
-
Integrated sequence
CTGCACGTCGCATGGAGACCACCGTGAACGCCCACCAAATATTGCCCAAGGTCTTACATAAGAGGACTCTTGGACTCTCAGCAATGTCAACGACCGACCT| |TGAGGCATACTTCAAAGACTGTTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTG
Host Sequence
Chromosome
chr20
Cytoband
q13.31
Reference genome
GRCh37/hg19
Start
56142581/57567525 (Hg38)
End
56142581/57567525 (Hg38)
Orient
+
Location type
Intergenic
Nearest miRNA
hsa-mir-103a-2/Upstream/245934; hsa-mir-1-1/Downstream/1250090;
Nearest TSS
ENST00000382410/Upstream/3441; ENST00000613231/Downstream/33675;
Nearest CpG islands
None/Target, chr20-CpG: 39/Upstream/42331, chr20-CpG: 39/Downstream/84671
Nearby gene
PCK1(No orient, 1067)
Upstream sequence
GAGAGTCTTAGCTCCAGACACGTTGGCTTGTTAGAATATCAAAACCACCGAAGGGGAAAAACCACTTACTGGAATTAAATGCTATCTGCTGTATTAGTTT
Downstream sequence
AAATcagtggcgttcaaacttgtttctccttttcactgcggaacacgttcttgacatgtacttgactcagagtcccatgtctaaaggagacagagcccaa
Reference
Sung, W. K., et al. Genome-wide survey of recurrent HBV integration in hepatocellular carcinoma. Nat Genet,2012, 44(7): 765-769.
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