Basic Information
VIS ID
TVIS10014994
Fusion event
HBV-chr5 integration
Validated
No
Detection method
WGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2012
PubMed ID
22634754
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
HBVgp3 X protein;HBVgp4 precore/core protein
Start
1820
Orient
-
Integrated sequence
TTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCA| |ACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTAT
Host Sequence
Chromosome
chr5
Cytoband
p15.33
Reference genome
GRCh37/hg19
Start
1302542/1302427 (Hg38)
End
1302542/1302427 (Hg38)
Orient
+
Location type
Intergenic
Nearest miRNA
hsa-mir-4635/Upstream/239453; hsa-mir-10397/Downstream/6883;
Nearest TSS
ENST00000502646/Upstream/7358; ENST00000605200/Downstream/19402;
Nearest CpG islands
None/Target, chr5-CpG: 87/Upstream/6572, chr5-CpG: 18/Downstream/32535
Nearby gene
TERT(No orient, 7379)
Upstream sequence
CAGCCTCCCAGCTGCCCCTGCAGTGGGTCCCATGGGATAACAGGTGGTCACAGAAACTGTGAATATGTCAAGAGACGGTGTATCCCCAGTCTACGAAGAA
Downstream sequence
acaggatctcattcttttttatggctgcgtagtactccattgtgtatgtgcaccacattttctttttccattcgtctgttgatggacactgaggttgctt
Reference
Sung, W. K., et al. Genome-wide survey of recurrent HBV integration in hepatocellular carcinoma. Nat Genet,2012, 44(7): 765-769.
Curate