Basic Information
VIS ID
TVIS10014995
Fusion event
HBV-chr5 integration
Validated
No
Detection method
WGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2012
PubMed ID
22634754
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
HBVgp3 X protein;HBVgp4 precore/core protein
Start
1824
Orient
+
Integrated sequence
TTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTT| |TTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAAG
Host Sequence
Chromosome
chr5
Cytoband
p15.33
Reference genome
GRCh37/hg19
Start
1302548/1302433 (Hg38)
End
1302548/1302433 (Hg38)
Orient
+
Location type
Intergenic
Nearest miRNA
hsa-mir-4635/Upstream/239459; hsa-mir-10397/Downstream/6877;
Nearest TSS
ENST00000502646/Upstream/7364; ENST00000605200/Downstream/19396;
Nearest CpG islands
None/Target, chr5-CpG: 87/Upstream/6578, chr5-CpG: 18/Downstream/32529
Nearby gene
TERT(No orient, 7385)
Upstream sequence
ACCTGAAGCCTGCAGCCTCCCAGCTGCCCCTGCAGTGGGTCCCATGGGATAACAGGTGGTCACAGAAACTGTGAATATGTCAAGAGACGGTGTATCCCCA
Downstream sequence
tctcattcttttttatggctgcgtagtactccattgtgtatgtgcaccacattttctttttccattcgtctgttgatggacactgaggttgcttccaaac
Reference
Sung, W. K., et al. Genome-wide survey of recurrent HBV integration in hepatocellular carcinoma. Nat Genet,2012, 44(7): 765-769.
Curate