Basic Information
VIS ID
TVIS10014996
Fusion event
HBV-LINC02226 integration
Validated
No
Detection method
WGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2012
PubMed ID
22634754
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
HBVgp1 Polymerase;HBVgp4 precore/core protein
Start
2441
Orient
-
Integrated sequence
CTGTTGTTAGACGACGAGGCAGGTCCCCTAGAAGAAGAACTCCCTCGCCTCGCAGACGAAGGTCTCAATCGCCGCGTCGCAGAAGATCTCAATCTCGGGA| |ATCTCAATGTTAGTATTCCTTGGACTCATAAGGTGGGGAACTTTACTGGGCTTTATTCTTCTACTGTACCTGTCTTTAATCCTCATTGGAAAACACCATC
Host Sequence
Chromosome
chr5
Cytoband
p15.31
Reference genome
GRCh37/hg19
Start
8407974/8407861 (Hg38)
End
8407974/8407861 (Hg38)
Orient
-
Location type
Intronic
Target gene
LINC02226
Nearest miRNA
hsa-mir-4277/Upstream/1579940; hsa-mir-10397/Downstream/53064;
Nearest TSS
ENST00000502646/Upstream/483569; ENST00000605918/Downstream/37674;
Nearest CpG islands
None/Target, chr5-CpG: 87/Upstream/538134, chr5-CpG: 88/Downstream/49458
Upstream sequence
CCCAGGGCTGCCTCCAGGTCCGGACGCGGGGCGTCGGGCTCCGGGCACCACGAATGCCGGACGTGAAGGGGAGGACGGAGGCGCGTAGACGCGGCTGGGG
Downstream sequence
AATACACTTATTTCTAAACCTGGATTCCTTTTCTAAATTCCAAGCCTGAGATTCCAAACTGATTCTTGCAAAAGATGACATCCACCTCAAAATTCATTAA
Reference
Sung, W. K., et al. Genome-wide survey of recurrent HBV integration in hepatocellular carcinoma. Nat Genet,2012, 44(7): 765-769.
Curate