Basic Information
VIS ID
TVIS10014999
Fusion event
HBV-chr6 integration
Validated
No
Detection method
WGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2012
PubMed ID
22634754
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
HBVgp1 Polymerase;HBVgp2 pre-S2/S;HBVgp2
Start
580
Orient
-
Integrated sequence
CTAATTCCAGGATCCTCAACAACCAGCACGGGACCATGCCGGACCTGCATGACTACTGCTCAAGGAACCTCTATGTATCCCTCCTGTTGCTGTACCAAAC| |CTTCGGACGGAAATTGCACCTGTATTCCCATCCCATCATCCTGGGCTTTCGGAAAATTCCTATGGGAGTGGGCCTCAGCCCGTTTCTCCTGGCTCAGTTT
Host Sequence
Chromosome
chr6
Cytoband
p25.1
Reference genome
GRCh37/hg19
Start
6068443/6068210 (Hg38)
End
6068443/6068210 (Hg38)
Orient
+
Location type
Intergenic
Fragile sites / regions
FRA6B
Nearest miRNA
hsa-mir-3691/Upstream/919888; hsa-mir-10398/Downstream/101094;
Nearest TSS
ENST00000381078/Upstream/60605; ENST00000230568/Downstream/156598;
Nearest CpG islands
None/Target, chr6-CpG: 120/Upstream/9779, chr6-CpG: 72/Downstream/477927
Nearby gene
NRN1(No orient, 60604)
Upstream sequence
cttgggaggctgaggcacaagaatcacttgaacccagcaggtggagtctgcagtgagccaagatcacaccactgtagtccagcctgggcaacagagcaag
Downstream sequence
gagctgaaagccatgaaccgagttttacccacatatttattgacagcaagccagtgataagcattatttctatagattacagattaactaaaacgggaaa
Reference
Sung, W. K., et al. Genome-wide survey of recurrent HBV integration in hepatocellular carcinoma. Nat Genet,2012, 44(7): 765-769.
Curate