Basic Information
VIS ID
TVIS10015000
Fusion event
HBV-chr9 integration
Validated
No
Detection method
WGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2012
PubMed ID
22634754
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
HBVgp3 X protein;HBVgp4 precore/core protein
Start
1827
Orient
+
Integrated sequence
AAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTT| |CACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAAGAAT
Host Sequence
Chromosome
chr9
Cytoband
p21.1
Reference genome
GRCh37/hg19
Start
32179450/32179452 (Hg38)
End
32179450/32179452 (Hg38)
Orient
+
Location type
Intergenic
Fragile sites / regions
FRA9C
Nearest miRNA
hsa-mir-101-2/Upstream/3290497; hsa-let-7a-1/Downstream/929240;
Nearest TSS
ENST00000422679/Upstream/797962; ENST00000541043/Downstream/205151;
Nearest CpG islands
None/Target, chr9-CpG: 64/Upstream/924687, chr9-CpG: 59/Downstream/204970
Upstream sequence
TTCATCATTTAGAAAATATTTCTAACAAATATTTAGGTTGAATACCTAGTCATGCATTATAATAAATAACTATTTAATCTTTTCTTTTTTTGTTTTCACG
Downstream sequence
TTGCCTGCAAACATGAATTTATATGCAGGCAAACTCTTTCTCAGTCTTCTTAAGGAAACCATCATGGAATGTGTGCGTTTCAAACTTCAGAGTTGATTTC
Reference
Sung, W. K., et al. Genome-wide survey of recurrent HBV integration in hepatocellular carcinoma. Nat Genet,2012, 44(7): 765-769.
Curate