Basic Information
VIS ID
TVIS10015003
Fusion event
HBV-chr11 integration
Validated
No
Detection method
WGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2012
PubMed ID
22634754
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
HBVgp1 Polymerase;HBVgp4 precore/core protein
Start
2308
Orient
+
Integrated sequence
TTTCACATTTCTTGTCTCACTTTTGGAAGAGAAACAGTTATAGAGTATTTGGTGTCTTTCGGAGTGTGGATTCGCACTCCTCCAGCTTATAGACCACCAA| |ATGCCCCTATCCTATCAACACTTCCGGAGACTACTGTTGTTAGACGACGAGGCAGGTCCCCTAGAAGAAGAACTCCCTCGCCTCGCAGACGAAGGTCTCA
Host Sequence
Chromosome
chr11
Cytoband
p12
Reference genome
GRCh37/hg19
Start
41906694/41885144 (Hg38)
End
41906694/41885144 (Hg38)
Orient
+
Location type
Intergenic
Nearest miRNA
hsa-mir-1343/Upstream/5874940; hsa-let-7a-2/Downstream/1674512;
Nearest TSS
ENST00000527297/Upstream/8510; ENST00000530300/Downstream/200314;
Nearest CpG islands
None/Target, chr11-CpG: 30/Upstream/5374677, chr11-CpG: 49/Downstream/1426745
Nearby gene
LOC105376639(-9359) ;
Upstream sequence
CTATATGGTTATTTATACCATTAATAGATGAGGCTTAAGAAGCCTTAGGAAATCTAACTTTTCAAATGTTTTGTACCTAGAACATGGTAGCAATGAAATT
Downstream sequence
TAAAAACATATTTTCTCTCCTTAAAGATTAGACCCCTACCTAGACTGGCATTGCCTCCTTTTCTCTCAAATGGTAAGATTTTTCCCCCTCTTATATAGTG
Reference
Sung, W. K., et al. Genome-wide survey of recurrent HBV integration in hepatocellular carcinoma. Nat Genet,2012, 44(7): 765-769.
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