Basic Information
VIS ID
TVIS10015004
Fusion event
HBV-chr11 integration
Validated
No
Detection method
WGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2012
PubMed ID
22634754
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
HBVgp3 X protein
Start
1786
Orient
-
Integrated sequence
AACGACCGACCTTGAGGCATACTTCAAAGACTGTTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGT| |AGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCT
Host Sequence
Chromosome
chr11
Cytoband
p12
Reference genome
GRCh37/hg19
Start
41907626/41886076 (Hg38)
End
41907626/41886076 (Hg38)
Orient
+
Location type
Intergenic
Nearest miRNA
hsa-mir-1343/Upstream/5875872; hsa-let-7a-2/Downstream/1673580;
Nearest TSS
ENST00000527297/Upstream/9442; ENST00000530300/Downstream/199382;
Nearest CpG islands
None/Target, chr11-CpG: 30/Upstream/5375609, chr11-CpG: 49/Downstream/1425813
Upstream sequence
ACTTAAGGGCTGGGCTTTGTCAAGTTTATATTCCCCTGTATTTCTGTCTGGATGCAGTCACAGTGCAGTATTCACGGTAGATACTCAATAAAAATCTTTA
Downstream sequence
GTTCTTTAGAGCTGTCCTACTTACTTTTAGGAACCATGTCTATTTGGGGCTTTTATTAATTTTTGCTAATATGGAAAGTATCATCATTTCTATCTTCTTT
Reference
Sung, W. K., et al. Genome-wide survey of recurrent HBV integration in hepatocellular carcinoma. Nat Genet,2012, 44(7): 765-769.
Curate