NBAS _LIHC.png
Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS10015026
Fusion event
HBV-NBAS integration
Validated
No
Detection method
WGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2012
PubMed ID
22634754
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
HBVgp3 X protein;HBVgp4 precore/core protein
Start
1826
Orient
-
Integrated sequence
AAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTT| |TCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAAGAA
Host Sequence
Chromosome
chr2
Cytoband
p24.3
Reference genome
GRCh37/hg19
Start
15366499/15226375 (Hg38)
End
15366499/15226375 (Hg38)
Orient
+
Location type
Intronic
Target gene
NBAS
miRNAs that regulate target gene
hsa-mir-432-5p
Nearest miRNA
hsa-mir-3125/Upstream/2488931; hsa-mir-10b/Downstream/4122054;
Nearest TSS
ENST00000437798/Upstream/35972; ENST00000438178/Downstream/12311;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/590690, chr2-CpG: 27/Downstream/334640
Upstream sequence
TTCATTAGGATTTTTTGTTTGTTTCCTTGTTTTTAAAATATTTGACAGCAGTATTTTCTTAATTCCAGGTTTGACAGATATATGCTTTTAGAACATTCTT
Downstream sequence
AGTGTTGAATTTTTTTTAAAGAAAACTTACTTTTCTTAAGCAAACAAATTCTTAACACGAACTAGAAATTGATATTTTCTTCTTGAAATATGATGTTATA
Reference
Sung, W. K., et al. Genome-wide survey of recurrent HBV integration in hepatocellular carcinoma. Nat Genet,2012, 44(7): 765-769.
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