Basic Information
VIS ID
TVIS10015028
Fusion event
HBV-chr13 integration
Validated
No
Detection method
WGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2012
PubMed ID
22634754
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
HBVgp1 Polymerase;HBVgp2 pre-S2/S;HBVgp2
Start
754
Orient
-
Integrated sequence
TCAGCCCGTTTCTCCTGGCTCAGTTTACTAGTGCCATTTGTTCAGTGGTTCGTAGGGCTTTCCCCCACTGTTTGGCTTTCAGTTATATGGATGATGTGGT| |ATTGGGGGCCAAGTCTGTACAGCATCTTGAGTCCCTTTTTACCGCTGTTACCAATTTTCTTTTGTCTTTGGGTATACATTTAAACCCTAACAAAACAAAG
Host Sequence
Chromosome
chr13
Cytoband
q21.33
Reference genome
GRCh37/hg19
Start
69086031/68511899 (Hg38)
End
69086031/68511899 (Hg38)
Orient
+
Location type
Intergenic
Fragile sites / regions
FRA13B
Nearest miRNA
hsa-mir-1297/Upstream/2293575; hsa-mir-1267/Downstream/9186113;
Nearest TSS
ENST00000623511/Upstream/1139512; ENST00000627910/Downstream/366481;
Nearest CpG islands
None/Target, chr13-CpG: 551/Upstream/1280572, chr13-CpG: 34/Downstream/472873
Upstream sequence
aaaagaaaaacccattttcggaggaaaaattcaagccttctgcagaaatttgcataagtaacgaggagccaaatattaatctccaagataatatgaaaga
Downstream sequence
tgtctccagggcatgtcagagaccttcatggcagccccacccatcacaggcctggaagcctaagagaaaaaatagttaggtggtccaagtccagggctcc
Reference
Sung, W. K., et al. Genome-wide survey of recurrent HBV integration in hepatocellular carcinoma. Nat Genet,2012, 44(7): 765-769.
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