Basic Information
VIS ID
TVIS10015032
Fusion event
HBV-chrX integration
Validated
No
Detection method
WGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2012
PubMed ID
22634754
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
HBVgp1 Polymerase;HBVgp2 pre-S1/pre-S2/S
Start
2928
Orient
-
Integrated sequence
CTTGGGAACAAGATCTACAGCATGGGGCAGAATCTTTCCACCAGCAATCCTCTGGGATTCTTTCCCGACCACCAGTTGGATCCAGCCTTCAGAGCAAACA| |CCGCAAATCCAGATTGGGACTTCAATCCCAACAAGGACACCTGGCCAGACGCCAACAAGGTAGGAGCTGGAGCATTCGGGCTGGGTTTCACCCCACCGCA
Host Sequence
Chromosome
chrX
Reference genome
GRCh37/hg19
Start
31137264/31137264 (Hg38)
End
31137264/31137264 (Hg38)
Orient
+
Location type
Intergenic
Fragile sites / regions
FRAXC
Nearest miRNA
hsa-mir-23c/Upstream/1562906; hsa-let-7f-2/Downstream/1446392;
Nearest CpG islands
None/Target, chrX-CpG: 62/Upstream/65051, chrX-CpG: 51/Downstream/129123
Upstream sequence
TGGCCTTGGGGGAATGATGACTGCCGTTCCCCAAAAACCAATTGACGAAGCATTGCTAAGAAGATGAAAAGTGCCTTTCTGGCAAACCTGGTAATAAAGC
Downstream sequence
TATTTAAAAAGTAAGTAAGTAAGTAACAACAACTAAATTAAAATAAAAACAAAGTACTGCAGTCCAGTCAATACTTTTTTGTAACATAACTGCGTGCTTT
Reference
Sung, W. K., et al. Genome-wide survey of recurrent HBV integration in hepatocellular carcinoma. Nat Genet,2012, 44(7): 765-769.
Curate