Basic Information
VIS ID
TVIS10015038
Fusion event
HBV-chr3 integration
Validated
No
Detection method
WGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2012
PubMed ID
22634754
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
HBVgp4 precore/core protein
Start
1974
Orient
+
Integrated sequence
CAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAAGAATTTGGAGCTACTGTGGAGTTACTCTCGTTTTTGCCTTCTGACTTCTTT| |CCTTCAGTACGAGATCTTCTAGATACCGCCTCAGCTCTGTATCGGGAAGCCTTAGAGTCTCCTGAGCATTGTTCACCTCACCATACTGCACTCAGGCAAG
Host Sequence
Chromosome
chr3
Cytoband
q28
Reference genome
GRCh37/hg19
Start
191648205/191930416 (Hg38)
End
191648205/191930416 (Hg38)
Orient
+
Location type
Intergenic
Nearest miRNA
hsa-let-7g/Upstream/2100407; hsa-mir-3137/Downstream/3204090;
Nearest TSS
ENST00000440867/Upstream/361881; ENST00000452657/Downstream/99464;
Nearest CpG islands
None/Target, chr3-CpG: 148/Upstream/66905, chr3-CpG: 177/Downstream/477616
Upstream sequence
ttaccttcttttcaagggcctgtttcccttgcctccataactgttgtgggtattgacagccaggcttctaaacctcttaaaactccccaactctggtgcc
Downstream sequence
ccactgcgccctgccAAGTGTTTTGAATTTTtatgatgtgtggtgaatttgtttaattttcttgtaaatccatcaatatttcaagctattttaatgagta
Reference
Sung, W. K., et al. Genome-wide survey of recurrent HBV integration in hepatocellular carcinoma. Nat Genet,2012, 44(7): 765-769.
Curate