VISDB Viral Integration Site DataBase

VIS ID

TVIS10015039

Fusion event

HBV-TERT integration

Validated

Yes

Detection method

PCR and Sanger sequencing

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Good

Reported year

2012

PubMed ID

Virus name

HBV

Reference genome

Region type

HBVgp1 Polymerase;HBVgp2 pre-S2/S;HBVgp2

Start

130

End

812

Orient

-

Integrated sequence

CGAGGATTGGGGACCCTGCGCTGAACATGGAGAACATCACATCAGGATTCCTAGGACCCCTTCTCGTGTTACAGGCGGGGTTTTTCTTGTTGACAAGAATCCTCACAATACCGCAGAGTCTAGACTCGTGGTGGACTTCTCTCAATTTTCTAGGGGGAACTACCGTGTGTCTTGGCCAAAATTCGCAGTCCCCAACCTCCAATCACTCACCAACCTCTTGTCCTCCAACTTGTCCTGGTTATCGCTGGATGTGTC

Chromosome

chr5

Cytoband

p15.33

Reference genome

Start

End

1269360/1269245 (Hg38)

Orient

+

Location type

Intronic

Target gene

miRNAs that regulate target gene

hsa-mir-138-5p ; hsa-mir-498 ; hsa-mir-193b-3p ; hsa-mir-335-5p ; hsa-mir-512-5p ; hsa-mir-1207-5p ; hsa-mir-1266-5p ; hsa-mir-1182 ; hsa-mir-181a-5p ; hsa-mir-6776-3p ; hsa-mir-197-3p ; hsa-mir-6740-3p ; hsa-mir-6760-3p ; hsa-mir-532-5p ; hsa-mir-3064-5p ; hsa-mir-422a ; hsa-mir-346 ; hsa-mir-1226-3p ; hsa-mir-1255a ; hsa-mir-1255b-5p ; hsa-mir-143-3p ; hsa-mir-3161 ; hsa-mir-3605-5p ; hsa-mir-3620-3p ; hsa-mir-3682-3p ; hsa-mir-4323 ; hsa-mir-4712-3p ; hsa-mir-4733-3p ; hsa-mir-4758-3p ; hsa-mir-4770 ; hsa-mir-6088 ; hsa-mir-7112-3p

Nearest miRNA

hsa-mir-4635/Upstream/205616; hsa-mir-10397/Downstream/40065;

Nearest TSS

Nearest CpG islands

None/Target, chr5-CpG: 87/Upstream/11483, chr5-CpG: 26/Downstream/1418

Nearest cancer related gene

TERT(OG, No orient, 0)

Upstream sequence

ATCAACAGGACACTGACTTCTAATGGGAGAAGGTGGAGTTTTGTGTGGGCCCAGAAACCACACAACTAATAACAACCTTCAGCCTGCAGGACAGCCCCTG

Downstream sequence

AGACGCTTGCAGCCTACTGCAAAAACAAGACCTGTTATTTTCGGGAAGCGCTATAGGTGGTCACCTTAAAAAGAGGCTTTCCggctgggcgtgatggctc

Target sequence

GAGGATGGAGCCCTGCGGGATCCCCTGGCACTGGACGTAGGACCTGGGGCGGGAAGACACAGGTGAGAGACGGGCAGGGCATGTGCTGGACATGCGTACACTCAAACCGAGCCACACACAGACACAGAACCTCATACACACAAACGACACGTCTACCATTCAGCCGGCAAACACCTCAGAAACATACCAGATGAGACCTCTGAACAAACAATCCCTGCTCCCCACTCTCACCATGCACTGGGGCGGCTGAAACAG