VISDB Viral Integration Site DataBase

VIS ID

TVIS10015040

Fusion event

HBV-TERT integration

Validated

Yes

Detection method

PCR and Sanger sequencing

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Good

Reported year

2012

PubMed ID

Virus name

HBV

Reference genome

Region type

HBVgp4 precore/core protein

Start

2027

End

2557

Orient

+

Integrated sequence

AGAGTCTCCTGAGCATTGTTCACCTCACCATACTGCACTCAGGCAAGCAATTCTTTGCTGGGGGGAACTAATGACTCTAGCTACCTGGGTGGGTGTTAATTTGGAAGATCCAGCGTCTAGAGACCTAGTAGTCAGTTATGTCAACACTAATATGGGCCTAAAGTTCAGGCAACTCTTGTGGTTTCACATTTCTTGTCTCACTTTTGGAAGAGAAACAGTTATAGAGTATTTGGTGTCTTTCGGAGTGTGGATTCG

Chromosome

chr5

Cytoband

p15.33

Reference genome

Start

End

1269904/1269789 (Hg38)

Orient

-

Location type

Intronic

Target gene

miRNAs that regulate target gene

hsa-mir-138-5p ; hsa-mir-498 ; hsa-mir-193b-3p ; hsa-mir-335-5p ; hsa-mir-512-5p ; hsa-mir-1207-5p ; hsa-mir-1266-5p ; hsa-mir-1182 ; hsa-mir-181a-5p ; hsa-mir-6776-3p ; hsa-mir-197-3p ; hsa-mir-6740-3p ; hsa-mir-6760-3p ; hsa-mir-532-5p ; hsa-mir-3064-5p ; hsa-mir-422a ; hsa-mir-346 ; hsa-mir-1226-3p ; hsa-mir-1255a ; hsa-mir-1255b-5p ; hsa-mir-143-3p ; hsa-mir-3161 ; hsa-mir-3605-5p ; hsa-mir-3620-3p ; hsa-mir-3682-3p ; hsa-mir-4323 ; hsa-mir-4712-3p ; hsa-mir-4733-3p ; hsa-mir-4758-3p ; hsa-mir-4770 ; hsa-mir-6088 ; hsa-mir-7112-3p

Nearest miRNA

hsa-mir-4635/Upstream/206317; hsa-mir-10397/Downstream/39521;

Nearest TSS

Nearest CpG islands

None/Target, chr5-CpG: 87/Upstream/12184, chr5-CpG: 26/Downstream/874

Nearest cancer related gene

TERT(OG, No orient, 0)

Upstream sequence

TGTGTGGGCCCAGAAACCACACAACTAATAACAACCTTCAGCCTGCAGGACAGCCCCTGAACACAGCCCCTTCCCCCTTGCAGTTCCTCACAGGAACTCA

Downstream sequence

TCTCTCTGTTCTTAGTTTTTGGGGCAACAGGTTTTGAAGACGTTTTTATTCAGAGGCCAAACTGGACCACGATGGGGACTAGAGCTTCGGGCCTGTCCGT

Target sequence

AGCGCTATAGGTGGTCACCTTAAAAAGAGGCTTTCCggctgggcgtgatggctcacacctgtaatcccagcactttgggaggccgaggtgggtggatcacctgaggtcaggagttcgagaccagcctggccaacatggcaaaaacccctctctactaaaaatacaaaaattagccaggcgcagggggtgggtgcctgtaatctcagctgctcgggaggctgaggcaggagaaatgctggaacccgggaggcggag