Basic Information
VIS ID
TVIS10015042
Fusion event
HBV-LOC105378532 integration
Validated
No
Detection method
WGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2012
PubMed ID
22634754
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
HBVgp1 Polymerase
Start
1159
Orient
+
Integrated sequence
CTTTGTATGCATGTATTCAATCTAAGCAGGCTTTCACTTTCTCGCCAACTTACAAGGCCTTTCTGTGTAAACAATACCTGAACCTTTACCCCGTTGCCCG| |GCAACGGCCAGGTCTGTGCCAAGTGTTTGCTGACGCAACCCCCACTGGCTGGGGCTTGGTCATGGGCCATCAGCGCATGCGTGGAACCTTTTCGGCTCCT
Host Sequence
Chromosome
chr10
Cytoband
q26.13
Reference genome
GRCh37/hg19
Start
125472276/123712760 (Hg38)
End
125472276/123712760 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA10D ; FRA10F ; FRA10A ; FRA10B
Target gene
LOC105378532
Nearest miRNA
hsa-mir-107/Upstream/1295693; hsa-mir-202/Downstream/1320023;
Nearest TSS
ENST00000439456/Upstream/46405; ENST00000446888/Downstream/63910;
Nearest CpG islands
None/Target, chr10-CpG: 68/Upstream/45634, chr10-CpG: 25/Downstream/144781
Upstream sequence
tctcagtttatcctcatgaagctttcagtctagcagaataaacaACTTCATTCAGTTTGGGCCAAAAaacaacaacaactacaacaacaacaacaGAAAC
Downstream sequence
CACCAAAACTGTGAGTCTAAGGTGTTAAACACATATTTTCTGGGTACATTCTGTTTACAAAGACACTGAGGGGGGCTTGAAGATGCAGGTCATGTGGCCT
Reference
Sung, W. K., et al. Genome-wide survey of recurrent HBV integration in hepatocellular carcinoma. Nat Genet,2012, 44(7): 765-769.
Curate