Basic Information
VIS ID
TVIS10015047
Fusion event
HBV-chr14 integration
Validated
No
Detection method
WGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2012
PubMed ID
22634754
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
HBVgp4 precore/core protein
Start
1993
Orient
+
Integrated sequence
CTTTGGGGCATGGACATCGACCCTTATAAAGAATTTGGAGCTACTGTGGAGTTACTCTCGTTTTTGCCTTCTGACTTCTTTCCTTCAGTACGAGATCTTC| |TAGATACCGCCTCAGCTCTGTATCGGGAAGCCTTAGAGTCTCCTGAGCATTGTTCACCTCACCATACTGCACTCAGGCAAGCAATTCTTTGCTGGGGGGA
Host Sequence
Chromosome
chr14
Cytoband
q32.13
Reference genome
GRCh37/hg19
Start
96085338/95619001 (Hg38)
End
96085338/95619001 (Hg38)
Orient
-
Location type
Intergenic
Nearest miRNA
hsa-mir-1260a/Upstream/481015; hsa-mir-1185-1/Downstream/4490418;
Nearest TSS
ENST00000550708/Upstream/45396; ENST00000555032/Downstream/1913;
Nearest CpG islands
None/Target, chr14-CpG: 35/Upstream/83473, chr14-CpG: 53/Downstream/94918
Upstream sequence
aagtctttaggcttgggactcagctcattcagtatggcctcatcttaatttaacaaattgaatctgcaaagatcctattttcaaatatgatcacatccca
Downstream sequence
aggctctagtagacataaattttggtaggggggcgggggacactatttatctcaccacaccctccataatttgatttgctgcttggtcagccctgtcttt
Reference
Sung, W. K., et al. Genome-wide survey of recurrent HBV integration in hepatocellular carcinoma. Nat Genet,2012, 44(7): 765-769.
Curate