Basic Information
VIS ID
TVIS10015051
Fusion event
HBV-chr19 integration
Validated
Yes
Detection method
PCR and Sanger sequencing
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Good
Reported year
2012
PubMed ID
22634754
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
HBVgp1 Polymerase;HBVgp2 pre-S2/S;HBVgp2
Start
2852
End
3171
Orient
-
Integrated sequence
GGGCAGAATCTTTCCACCAGCAATCCTCTGGGATTCTTTCCCGACCACCAGTTGGATCCAGCCTTCAGAGCAAACACCGCAAATCCAGATTGGGACTTCAATCCCAACAAGGACACCTGGCCAGACGCCAACAAGGTAGGAGCTGGAGCATTCGGGCTGGGTTTCACCCCACCGCACGGAGGCCTTTTGGGGTGGAGCCCTCAGGCTCAGGGCATACTACAAACTTTGCCAGCAAATCCGCCTCCTGCCTCCACC
Host Sequence
Chromosome
chr19
Cytoband
q12
Reference genome
GRCh37/hg19
Start
30315395/29824488 (Hg38)
End
30315672/29824765 (Hg38)
Orient
-
Location type
Intergenic
Nearest miRNA
hsa-mir-10395/Upstream/9425134; hsa-let-7e/Downstream/5297935;
Nearest TSS
ENST00000633603/Upstream/2756; ENST00000585655/Downstream/98879;
Nearest CpG islands
None/Target, chr19-CpG: 112/Upstream/11714, chr19-CpG: 21/Downstream/18768
Nearby gene
CCNE1(-171) ;
Nearest cancer related gene
CCNE1(OG, -171) ;
Upstream sequence
TGACTTCATACTTCTTGAGGCTCAAGTCTTTCttttttttttttttttttttttttttttttgagacagggacagggtctcgctctgtcaccaaggctgg
Downstream sequence
CATTTTTCAATGTATTTGATGGAAAGGAAACTTTAGACGTGGGCTTCAGGTGCAGCCTGTCTGCCTCCTGGTGCCCCCTGAGCTGGAAGTGAGGAGTCCA
Target sequence
agtgcaggggcacaatcttggctcactgcagcctctgcctcccgggtttaagcgattctcctgcctcagcctcctaagtagctgggactacaggcgtgtgccaccacacccagctaatttttgtatttttagtggagatggggttttgccatgttggccaggctggtctcaaactcctgacctcaggtgatctgcccatctcagccttccaaagtgctgggattacaggtgtgagccaccacacccagccTTGAG
Reference
Sung, W. K., et al. Genome-wide survey of recurrent HBV integration in hepatocellular carcinoma. Nat Genet,2012, 44(7): 765-769.
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